I would not advise that those with weak constitutions go see Osmosis Jones...some of the live-action parts are quite repugnant. =P I thought the idea of a society existing in one's body was really interesting, and the inventiveness shown about it was great (loved how a virus injected by vaccine is a stool pigeon), but the live-action parts of the movie were just horrible. They looked bad (like they were poorly/cheaply photographed), the actors were bad (except Bill Murray, although he was repulsive just because of his makeup most of the time), it was just.. bad. But Thrax was a very nicely designed villain and I liked Osmosis and Drix and the animation segments in general. I thought it was a little strange when Osmosis called Lia (or whatever Brandy's character's name is) 'Brandy' once, though (and why the hell was her dress so short? and did anyone catch the Kid Rock guy and the triple breasted dancer up on stage with him? o_o;;)... was that a joke or just an accident that happened to worm its way in? o_o;

Anyway, I probably wouldn't see it again or recommend it, unless you have a tolerance for horrible live action mixed with good-to-mediocre animation. Really, the only film I've seen that successfully mixed the two was Who Framed Roger Rabbit?, which is just one of the greatest movies of all time (even my Dad loves it, and he hates/falls asleep at everything).